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Mouse studies All in vivo experiments were conducted according to international principles of animal care and under the approval of the Danish Ethical Committee for Animal Research and the Danish Animal Experimentation Inspectorate

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Preclinical models evaluate how this interaction influences intracellular cyclic adenosine monophosphate (cAMP) levels and changes cellular signaling cascades

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It exerts a regulatory action on cellular and mitochondrial membrane permeability in association with an increase in membrane stability against the xenobiotic injury (Serviddio et al., 2014)