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The therapeutic application of GLP-1 agonists for obesity is grounded in well-established physiological mechanisms that extend beyond glucose regulation to encompass appetite control and energy homeostasis

This process requires the involvement of protein disulfide isomerase (PDI), ER redox protein 1 (ERO1), and GRP78 chaperone protein

Immediate medical attention is required if patients experience severe abdominal pain, particularly if localized, persistent, or accompanied by fever, which may indicate complications such as bowel obstruction, fecal impaction, or rarely, intestinal ischemia

However, it is safe for weanlings, yearlings, and young horses that may benefit from added digestive and immune support during growth or stress