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Glossary DKD Diabetic kidney disease RAAS Renin-angiotensin-aldosterone system TGF- Transforming growth factor beta TNF- Tumor necrosis factor-alpha STAT3 Signal transducer and activator of transcription 3 CCL20 Chemokine ligand 20 CCR6 Chemokine receptor 6 IFN- Interferon gamma Tregs Regulatory T-cells SGLT-2 Sodium-glucose cotransporter 2 BAR Bardoxolone methyl Nrf2 Nuclear factor erythroid-derived 2-related factor 2 BEACON Bardoxolone methyl evaluation in patients with chronic kidney disease and type 2 diabetes ALA Alpha-lipoic acid ALM Alpha lipoamide NRK-52E Rat renal tubular epithelial cell line NRK-52E Mfn1 Mitofusin 1 Drp1 Dynamin-related protein 1 RXR Retinoid X receptor- CDX2 Caudal-type homeobox transcription factor 2 CFTR Cystic fibrosis transmembrane conductance regulator EMT Epithelial-mesenchymal transition DAG Diacylglycerol PAMPs Pathogen-associated molecular patterns ULK1 Unc-51-like kinase 1 DAMPs Damage-associated molecular patterns WNT Wingless-type MMTV integration site family member HMGB1 High-mobility group box 1 MAMs Mitochondrial-associated endoplasmic reticulum membranes LN Lupus nephritis mTOR Mammalian target of rapamycin NLRP3 NOD-like receptor protein 3 IL-1 Interleukin-1 CCR2 Chemokine receptor 2 MCP-1 Monocyte chemoattractant protein 1 AGEs Advanced glycation end products NF-B Nuclear factor-B ROS Reactive oxygen species GBM Glomerular basement membrane FFAs Free fatty acids PPARs Peroxisome proliferator-activated receptors SREBPs Sterol regulatory element-binding proteins NOX NADPH oxidase MDA Malondialdehyde 4-HNE 4-hydroxynonenal PKC Hyperactivation of protein kinase C VEGF Vascular endothelial growth factor 8-OHdG 8-hydroxy-2-deoxyguanosine ADA American Diabetes Association HIF-1 Hypoxia-inducible factor-1 CTLs Cytotoxic T cells NADPH Nicotinamide adenine dinucleotide phosphate T2DM Type 2 diabetes mellitus DCs Dendritic cells CDCs Conventional DCs PDCs Plasmacytoid DCs APCs Antigen-presenting cells MHC-II Major Histocompatibility Complex Class II Bregs regulatory B cells PD-L1 Programmed death-ligand 1 FcRIIb Fc Gamma Receptor IIb ICAM-1 lntercellular adhesion molecule-1 C3a Complement component 3a DCCT Diabetes Control and Complications Trial RAGE Receptor for advanced glycation end products PI3K/AKT Phosphatidylinositol 3-kinase/protein kinase B CREDENCE Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation NETs Neutrophil extracellular traps eGFR Estimated glomerular filtration rate GLP-1 RAs Glucagon-like peptide-1 receptor agonists AMPLITUDE-O Assessment of the Effects of Efpeglenatide on Cardiovascular and Renal Outcomes HDL-C High-density lipoprotein cholesterol EASD European Association for the Study of Diabetes AMPK Adenosine monophosphate-activated protein kinase UKPDS United Kingdom Prospective Diabetes Study CKD Chronic kidney disease KDIGO Kidney Disease: Improving Global Outcomes TLR4 Toll-like receptor 4 DPP-4 Dipeptidyl Peptidase-4 SAVOR-TIMI Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus-Thrombolysis in Myocardial Infarction ACEIs Angiotensin-converting enzyme inhibitors ARBs Angiotensin II receptor blockers RENAAL Angiotensin II Antagonist Losartan IDNT Irbesartan Diabetic Nephropathy Trial ESKD End-stage kidney disease MRAs Mineralocorticoid receptor antagonists LDL Low-density lipoprotein HMG-CoA 3-Hydroxy-3-methylglutaryl coenzyme RhoA Ras homolog gene family, member A ROCK Rho-associated protein kinase PCSK9 Proprotein convertase subtilisin/kexin type 9 TCM Traditional Chinese Medicine Erk1/2 Extracellular signal-regulated kinases 1 and 2 ATMs Adipose tissue macrophages PMSCs Placenta-derived mesenchymal stem cells CTLA-4 Cytotoxic T lymphocyte-associated protein 4 MSCs Mesenchymal stem cells Akt Protein kinase B mTOR Mammalian target of rapamycin Nrf2 Nuclear factor erythroid 2-related factor 2 EVs Extracellular vesicles PGE2 Prostaglandin E2 IDO Indoleamine 2,3-dioxygenase VCAM-1 Vascular cell adhesion molecule-1 CNIs Calcineurin inhibitors RGD-HSA-TAC Arginine-Glycine-Aspartic acid-Human Serum Albumin-Tacrolimus NFAT Nuclear factor of activated T cells MAC Membrane attack complex IgAN IgA nephropathy CR2-fH Complement receptor 2 and complement factor H JAK-STAT Janus kinase-signal transducer and activator of transcription SOCS3 Suppressor of cytokine signaling 3 TYK2 Tyrosine kinase 2 CAR-Tregs Chimeric antigen receptor regulatory T cells PET-MRI Positron emission tomography-magnetic resonance imaging CXCR4 C-X-C chemokine receptor 4 ADC Antibody-drug conjugate AI Artificial intelligence

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Gently pinch a small fold of skin, insert the insulin needle at a shallow angle, and press the plunger slowly until the full dose is delivered

Clinical testing of the prodrug determined that despite reasonable kidney specificity it had low bioavailability (Lee, 1990)

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