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Mitochondrial ROS are increased under hypoxia, ischemia/reperfusion injury, chemical stress, drug treatment, and under many pathophysiological conditions (Srinivasan and Avadhani, 2012)
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Furthermore, given the prevalent BBB dysfunction in AD, the efficiency of hepatokines across the BBB may be significantly altered, impacting the therapeutic potential of these molecules
Isoliquiritigenin alleviates early brain injury after experimental intracerebral hemorrhage via suppressing ROS- and/or NF-B-mediated NLRP3 inflammasome activation by promoting Nrf2 antioxidant pathway