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That effect is magnified by the potential for reduced physical activity, resulting in a loss of strength and functionality

5.4 QT Prolongation Prolonged cardiac repolarization and QT interval, imparting a risk of developing cardiac arrhythmia and torsades de pointes, have been seen with treatment with macrolides, including azithromycin

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Both medications can lead to loss of lean muscle mass alongside fat, and adequate protein (0.7 to 1.0 grams per pound of body weight daily) helps preserve muscle