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49, 249279.10.1146/annurev.arplant.49.1.249 47 NoctorG.GomezL.VanackerH.FoyerC

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The age-related decline in melatonin and dampening of circadian rhythms likely contributes to sleep problems, metabolic and cognitive decline, and increased vulnerability to age-related diseases

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There was also higher mortality, HR 1.62, 95%CI 1.51-1.74, p 20 mmol/L (HR 1.47, 95%CI 1.36-1.59 compared to the reference group)

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Postischemic inhibition of cerebral cortex pyruvate dehydrogenase

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