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GLP-1 receptors are expressed throughout the central nervous system, including in the hypothalamus, which governs hunger and energy balance, and in the mesolimbic dopamine pathway the brain's reward circuit

Gydesen S, Andreassen KV, Hjuler ST, et al

People need to think mechanistically (MOAs, mechanism of action) about their treatment protocol, rather than just following lemming research

In January 2024, Gee began participating in the Mayo Clinic Diet, a companion program for those taking GLP-1 medications, in an effort to continue his weight loss and prepare for the time when he will no longer be taking Wegovy

The average follow-up duration was 3.8 months for the Wegovy group and 4.3 months for the tirzepatide group