glp 1 leptin The role of gut hormones in controlling the food intake. What is their role in emerging diseases? GLP-1RAs attenuated obesity and reversed

doi: 10.1038/bjp.2008.100 97 WebsterLRReisfieldGMDasguptaN

Early effect of single-dose sitagliptin administration on gastric emptying: crossover study using the 13 C breath test

Those on blood pressure medications, anticoagulants, or medications requiring specific stomach emptying rates should inform their prescriber, as GLP-1 medications slow gastric transit and may alter absorption rates

In the hospital settings, the implementation of GLP-1RAs may be particularly challenging, especially with once-weekly formulations, due to the potential need for discontinuation before surgical or diagnostic procedures or in the event of clinical deterioration

Clinical Trial Evidence: Landmark cardiovascular outcome trials (CVOTs) like the SELECT trial (for semaglutide) have shown a significant reduction in major adverse cardiovascular events (MACE), including heart attack, stroke, and cardiovascular death