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Alcohol consumption: Regular or heavy drinking depletes glutathione and increases oxidative stress, counteracting supplementation benefits

Mechanism 1: Mitochondrial Oxidative Stress EGCG at high concentrations generates reactive oxygen species (ROS) inside hepatocytes, a mechanism documented in multiple cell-culture and rodent studies [7]

Subcutaneous delivery bypasses the entire digestive tract

Some studies have suggested that GH and IGF-1 can increase muscle mass and reduce body fat, but its mostly been shown in animals and people with low levels of GH, like the elderly or those with a medical issue causing a deficiency

McGarry BE, Grabowski DC