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In addition to the absolute number, the type of bacteria present in the small intestine can also impact the signs and symptoms a person may experience

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Elevated intracellular cAMP activates protein kinase A (PKA), which phosphorylates the cAMP response element-binding protein (CREB), driving transcription of melanogenesis-related genes including tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), and dopachrome tautomerase (DCT) in melanocyte models

Similarly, PUFA supplementation induces gastrointestinal symptoms (diarrhea, abdominal pain and nausea) in patients without IBD 39