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There were no severe or serious AEs or AEs leading to withdrawal from the study

Enzymes called methyltransferases catalyze this process, using SAMe as a methyl donor

Hematoxylin and eosin (H&E) staining of major organs isolated from mice receiving DOX/LAAM GSH-CQDs (6 mg kg 1 ) treatment did not detect inflammatory infiltration or pathological damage (Fig

Factors that might warrant dose adjustment include body weight (with some research using weight-based dosing of 0.5-1.0 mcg/kg), response to first doses (with increases if effects are suboptimal or decreases if adverse effects occur), research phase (with possible dose increases in later phases of long-term protocols), and mix with other research compounds (which may need dose adjustments to account for combined effects)

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