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J Neurosci 36 , 35313540, (2016)

Eight cases (neuroendocrine carcinoma of the urine, uterine cervix, and pharynx and merkel cell carcinoma) were biopsied, and all other cases were resected

This is a rough measure of the adequacy of L-carnitine in the mitochondria, and when the ratio becomes too high, it suggests that the body is not capable of handling the demands of all the fat being used for calorie burning