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NICE guidelines recommend specific GLP-1 receptor agonists as part of a comprehensive approach to diabetes management (NG28) and, in specific circumstances, for weight management in individuals with obesity or overweight with comorbidities (TA875 for semaglutide, TA664 for liraglutide)

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Step 4: Seek Emergency Care if Necessary If you experience uncontrollable vomiting, severe abdominal pain, or signs of a serious allergic reaction (such as swelling of the throat or difficulty breathing), go to the nearest emergency room

Some researchers try to compensate by injecting more, figuring that extra volume will offset potency loss