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The gut microbiota axis (GMA) is a vital communication network between the gut and other organs (Sampson and Mazmanian Sarkis, 2015)

In animal reproduction studies, intravenous administration of pemetrexed to pregnant mice during the period of organogenesis was teratogenic, resulting in developmental delays and increased malformations at doses lower than the recommended human dose of 500 mg/m2

Despite a large amount of effort and many publications, most studies have testified effects of the extract pretreatment prior to acute APAP administration on serologic, histologic, and morphologic liver-related outcomes in vivo , but few studies have explored these effects in hepatic cell lines by culturing with the natural products and administrating APAP

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Radiobiologiia 25 (2): 200-3 (1985) Subcellular distribution of (3)H-hydrocortisone and its metabolites in the liver and kidney of intact and alloxan diabetic rats was investigated