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[DOI] [PubMed] [Google Scholar] 39.Ohlsson A., Rehnholm K., Shubham K., von Dbeln U

King, T

Irrefutable evidence from over 30 years ago showed that maternal folic acid supplementation in early pregnancy could protect against NTD (80,Reference Czeizel and Duds81) , leading to global recommendations for supplementation of women with folic acid at 400 g/d from preconception to the end of the first pregnancy trimester

Monitor patients receiving long-term therapy periodically for changes in renal function

Depression: A meta-analysis of 5 RCTs (n=574) found that NAC significantly improved depressive symptoms, particularly in individuals with high baseline symptom severity (Fernandes et al., J Clin Psychiatry, 2016) [73]