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doi:10.1172/jci33680

If cost is the primary barrier, I often recommend maximizing the dose of low-cost generic metformin and adding a sulfonylurea like glimepiride or glipizide, while closely monitoring for hypoglycemia. Regardless, an alternative to Synjardy is only viable if a healthcare professional thinks its a good fit for you

Because tirzepatide triggers insulin production and is commonly used to manage high blood sugar/type 2 diabetes, people who stop using it may experience spikes in their blood glucose levels if their bodies are unable to produce sufficient insulin without other antidiabetic medications being onboard, Ngo-Hamilton says

One of the most common issues is liver damage, including fatty liver, alcoholic hepatitis, and ultimately cirrhosis, which can be fatal