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Increased flux of key cellular energy regulators, including NAD + and SAM, may potentially define the therapeutic mechanism-of-action of NNMT inhibitors

Those with severe deficiency may need more frequent injections at first

Supplements, unlike drugs, do not have to go through rigorous studies to prove safety and efficacy before hitting store shelves, meaning they are subject to minimal oversight, says Zeller, who worked on supplement issues at the FDA in the 1990s

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