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For the kind of GLP-1 patches marketed for weight loss, the answer is a clear no

Branded tirzepatide can be more expensive, with retail prices often ranging from $1,400 to $1,600 monthly without insurance [3], though compounded tirzepatide offers a potentially more affordable alternative

Surg Neurol 13(5):337343 Beattie D, Smith J (2008) Serotonin pharmacology in the gastrointestinal tract: a review

Ann Intern Med 174(11):15281541

Effectiveness: A review of four randomized-controlled studies including 3,613 people with obesity but not diabetes found that the average weight loss with semaglutide was just under 12% compared to placebo