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Sperm cells rely heavily on antioxidant defenses to protect themselves from oxidative damage, and selenium plays a central role in that process through enzymes such as glutathione peroxidase 4 (GPx4), which helps support normal sperm development and motility.45 Just as importantly, selenium has been studied alongside NAC in human clinical research

The reduction of specific amino acids, such as glycine, serine, and proline, in the early stage may lead to an imbalance in macrophage polarization, thereby enhancing inflammatory responses in CIA mice (87)