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Treatment adherence Treatment adherence was assessed by calculating the proportion of days covered, defined as the number of days covered by the study drug (excluding the grace period) at 1 year after the date of filling the first prescription, divided by 365 days, for all patients who were alive at 1 year after drug initiation

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In this study, we observed a distinct pattern of CBF alterations in the prefrontal and limbic regions, suggesting a region-specific mechanism of dysfunction

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