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The clinical results have been striking

Safety Monitoring: According to FDA and manufacturer safety information, GLP-1 medications carry risks of serious side effects including thyroid tumors (in animal studies), pancreatitis, gallbladder disease, kidney problems, and others

Signal detection based on SOC levels The pharmacovigilance analysis revealed that adverse drug reactions (ADRs) associated with concomitant administration of GLP-1 receptor agonists and metformin spanned 27 distinct System Organ Classes (SOCs), as depicted in Fig

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2 The mechanism between osteoporosis and ferroptosis 2.1 Ferroptosis affects bone metabolism 2.1.1 Iron metabolism disorder The communication between osteoblasts and osteoclasts is essential for the fine regulation of bone remodeling in the process of maintaining bone homeostasis (9)