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Standard vs extended escalation The standard semaglutide escalation protocol increases the dose every four weeks: 0.25 mg for weeks 1-4, 0.5 mg for weeks 5-8, 1 mg for weeks 9-12, 1.7 mg for weeks 13-16, and 2.4 mg from week 17 onward

Some people report weight loss, but there is limited clinical evidence to support microdosing as an effective long-term weight management strategy

Authors contributions Writing review & editing, writing original draft (HZ, DW, QW, YWu, ZG, LW, YWang, QZ, LS, BS, GY, WL), formal analysis (HZ), conceptualization (HZ, GY, WL), supervision, and funding acquisition (GY, WL)

Imaging-based research: liver-fat imaging substudies in defined research populations

However, long-term human safety trials are lacking, so usage should be approached with caution