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Fasting serum insulin levels also decreased by up to 70.9% after 48 weeks, which may improve insulin resistance but may require additional monitoring in certain patients

And direction matters in body composition work

The benefits to cardiovascular health and diabetes also appear to reverse

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However, Mounjaro is not approved for weight loss, so if you're searching for tirzepatide for weight loss, you may want to consider other options such as Zepbound, which is specifically approved for that purpose