While safety monitoring was comprehensive, the trials were not specifically designed to detect rare adverse effects that might occur at rates lower than 1-2%, which would require much larger participant numbers
Never discontinue B12 injections without medical advice, even if you feel completely well, as deficiency can recur and cause irreversible neurological damage if left untreated
AOD-9604 was subsequently placed in Category 2 of the bulk drug substance nomination list, then later withdrawn from that nomination in April 2026
Who tends to benefit most Diagnosed deficiency from pernicious anemia, atrophic gastritis, inflammatory bowel disease, or after bariatric/intestinal surgery (NIH ODS)
The cyanocobalamin Injection, 1000mcg/mL comes in smaller 1mL vials so it may cost more to package this medication