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Increased cGMP also has an important anti-platelet, anti-aggregatory effect

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PMID: 25437411, PMCID: PMC5459391, DOI: 10.7326/m14-2308

The upper cervical nerves, particularly C1 through C3, share connections with the trigeminal nerve system in the face and head

For example, mortality studies have reported that among persons with SMI-SUD, cardiovascular causes account for the largest number of excess and premature deaths, suggesting that GLP-1 RAs hold promise to be transformative in this vulnerable population by reducing the ignominious mortality gap that exists between persons with SMI-SUD and the general population