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The INS gene is on chromosome 11p15.5, the PTPN22 gene is on chromosome 1p13, the CTLA4 gene is on chromosome 2q33, the IL2RA gene is on chromosome 10p15.1, and the IFIH1 gene is on chromosome 2q24

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Disassembly of the 26S complexes into the 20S proteasomes and the 19S regulatory particle can be caused by diminished ATP (Hoglinger et al., 2003), aspartate deficiency (Meul et al., 2020), or elevated reactive oxygen species (ROS) levels (Livnat-Levanon et al., 2014)

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