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Published 2022 Apr 14

The NDA submission was partly based on topline results from the ongoing single location BHV4157-206-RWE study (NCT06529146), in which troriluzole 200 mg administered orally once daily led to a 5070% slower rate of decline from baseline in the functional Scale for the Assessment and Rating of Ataxia (f-SARA) in all SCA genotypes at 3 years compared to an external control arm. Data from the BHV4157-206 study (NCT03701399) also demonstrated disease stabilization in the SCA3 genotype and a reduction in falls in all SCA genotypes compared to placebo over 48 weeks. If approved, troriluzole will be the first and only medication indicated for the treatment of SCA

Adverse events were in line with those previously observed for GLP-1 receptor agonists

Carnitine komt ook uit de endogene biosynthese in de lever en de nieren, maar in veel kleinere hoeveelheden

A faster metabolism allows the body to burn calories efficiently