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Laboratory markers include suppressed free T3 with normal TSH (euthyroid sick syndrome), elevated cortisol, and in severe cases, low LH and FSH indicating hypothalamic suppression

In the connection to inflammation, we showed that elevation of pro-inflammatory cytokine IL-6, increased anxiety at the lightdark test, and smaller hippocampal volume characterized at baseline (before any applied stress) those mice that become susceptible after social defeat stress (SDS) with social withdrawal and impaired transcriptomic-wide changes in ventral dentate gyrus, and that administration of LAC promoted behavioral resilience at the SDS paradigm in this susceptible phenotype [27]

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While there are various peptides that can be used for sleep improvement, some have demonstrated particular efficacy in this regard