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This medication acts on three hormone receptors in the bodyglucagon-like peptide-1 (GLP-1), gastric inhibitory polypeptide (GIP), and glucagon (GCG)

Disease states of GH excess (e.g., acromegaly) and GH deficiency (e.g., congenital isolated GH deficiency) are characterized by increased and decreased GH, IGF-I and insulin levels, respectively, where the GH/IGF-I relationship is reflected by a primary association

It is important to note that rapid improvement in glycemic control with any diabetes medication, including semaglutide, can occasionally trigger a condition called treatment-induced neuropathy of diabetes

J Environ Sci (China) 118:122129