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The EMPA-REG OUTCOME trial was a long-term, multicenter, randomized, double-blind, placebo-controlled trial of more than 7,000 patients from 42 countries with type 2 diabetes at high risk for cardiovascular events

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However, the metabolic benefits (improved lipid oxidation, reduced hepatic fat, enhanced energy expenditure) all trend in directions that should improve cardiovascular risk

A.LiuH.CornblattG.et al (2019)

It is the principal upstream regulator of GnRH secretion, integrating sex hormone feedback to determine when and how frequently GnRH and downstream LH is released