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DSIP is found in both free and protein-bound forms in the hypothalamus, limbic system, and pituitary gland, as well as in peripheral organs including the gut secretory cells, pancreas (where it co-localises with glucagon), and plasma with brain and plasma DSIP concentrations showing a marked diurnal variation that correlates with circadian rhythm in humans, with levels lowest in the morning and higher in the afternoon

One important role for changes in synaptic plasticity is its involvement in sustained antidepressant effect

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Genitourinary system Structure of the genitourinary system The most important component of the urinary system is the kidneys, which are paired organs whose parenchyma is made up of nephrons