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Although discontinuation due to AEs does not always correlate directly with dose escalation [66], higher discontinuation rates have been reported in older adults [76]

10.1007/s00018-008-7526-3 Cell Mol

After feeling like an outsider for much of his life, Asprey was thrilled to discover that the rest of the world was beginning to catch up with him

However, if extremely high doses are given for a long time, pyridoxine can cause nerve damage leading to numbness or tingling in the hands and feet (peripheral neuropathy)