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MedicalDaily Evidence Check The evidence base for BPC-157, TB-500, and MOTS-C consists of animal studies, small pilot human trials, and anecdotal clinical reports, none of which meet the standard of a Phase 3 randomized controlled trial required for FDA drug approval

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The enzyme methionine synthase needs methylcobalamin as a cofactor

Investigation of TB-500 metabolism, Ghent University project

Study Design & Methodology Male Wistar rats (1216 weeks old) were subjected to surgical detachment of the quadriceps muscle from its attachments at the femur and iliac bone