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At a Glance What It Is & Composition Tirzepatide is a single 39-amino-acid synthetic peptide engineered as a dual agonist : one molecule that binds and activates both the glucose-dependent insulinotropic polypeptide (GIP) receptor and the glucagon-like peptide-1 (GLP-1) receptor

Protein crystals for St-GSS1 were obtained by optimisation of JCSG D9 (1.4 M D-malic acid) with the addition of 2.5 mM -EC, 2.5 mM ADP, 5 mM MgCl 2 and St-GSS1 at 3.75 mg/ml final concentration

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[PMC free article: PMC2782388] [PubMed: 19307470] 497

If nothing changes, that is still useful information: it may mean the bottleneck is elsewhere, or the chosen form is not a good match