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doi: 10.1016/j.injury.2004.12.037 182 MorrisGBerkMGaleckiPMaesM

Signs include: Hives or widespread rash beyond the injection site Swelling of face, lips, tongue, or throat Difficulty breathing or wheezing Rapid heartbeat Feeling faint or losing consciousness These symptoms require immediate medical attention

A small number of users with sensitive skin experience mild initial scalp tingling, which typically resolves within the first week

In the chronic inflammatory state, TNF- shifts the predominant cytokine environment towards pro-inflammatory cytokines, such as IL-1, IL-6, IL-17, IL-22, and interferon gamma (IFN-), while simultaneously reducing the secretion of anti-inflammatory cytokines, in particular IL-4 and IL-10 [12,13]