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Research shows that stepwise dose increases over 1620 weeks produce better tolerability and sustained weight loss compared to rapid dose escalation

Mechanistic studies indicated that these effects were not driven by acute insulinotropic activity, but by -cell preservation and enhanced glucose uptake

This observation is clinically meaningful, as visual disturbances impact daily functioning and quality of life 28

Given that there are several subtypes of IBS and that the conditions etiology and symptom profiles vary, this is another limitation of the study

This lowers the amount of useful creatine, but it doesnt make the supplement unsafe