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Use consistently to see improvement in lip brightness and tone

Current expectations suggest ~ 10% of beneficiaries will qualify under defined BMI + comorbidity criteria

Evidence base for the medications involved The compounds themselves are well studied: GLP-1 receptor agonists (semaglutide, liraglutide, dulaglutide) and GIP/GLP-1 dual agonists (tirzepatide), with trial programs including STEP (semaglutide, The New England Journal of Medicine , 2021), SURMOUNT (tirzepatide, NEJM 2022), and SURMOUNT-OSA (tirzepatide for obstructive sleep apnea, NEJM 2024)

Crossing State Lines and International Travel : GLP-1 medications are not controlled substances and are allowed across state lines and internationally

Metformin: Enhances blood sugar control