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A 2015 meta-analysis found that NAC reduced chronic bronchitis or COPD exacerbations, though later research has been mixed, including a 2024 trial in mild-to-moderate COPD that did not find a significant reduction in overall exacerbation rates with high-dose NAC.1 22 Fertility Oxidative stress can damage sperm, eggs, and the reproductive environment, which is one reason antioxidants are often studied in fertility research

If drinking affects your sleep, you may also find it harder to exercise, prepare healthy meals or stay consistent with your routine

The crossover trial by Tempesta et al 21 was evaluated using the RoB 2 crossover tool, and judgments were consistent with other RCTs, showing some concerns in the randomization and measurement domains