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A pooled post-hoc analysis of neuropsychiatric safety data across weight management trials with liraglutide revealed a small numerical imbalance in suicidal ideation with liraglutide compared with placebo

Ca2+-dependent calmodulin binding to FcRn affects immunoglobulin G transport in the transcytotic pathway

Liepelt I, Reimold M, Maetzler W, Godau J, Reischl G, Gaenslen A, et al

This means lighter individuals experience higher peak concentrations relative to their body weight, which may explain why they often report more intense side effects and a stronger wearing-off effect

This hypothesis can now be tested in a follow-up study