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Hyperammonemia (a determining factor in its pathogenesis) leads to brain dysfunction associated with neuropsychiatric and neurologic complications

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Our experiments in mouse models of mild hyperhomocysteinemia caused by a deficiency in cystathionine beta-synthase in CBS +/ (heterozygous deficient) mice found that increased plasma total homocysteine caused abnormal responses to endothelium-dependent vasodilators