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Expanded molecular features of carnitine acyl-carnitine translocase (CACT) deficiency by comprehensive molecular analysis

For years, many of our members struggled with traditional diet and exercise advice that failed to account for hormonal imbalances and metabolic set points

10.1186/s12915-017-0462-7 111 ZhouJ.ZhangJ.LiJ.GuanY.ShenT.LiF.et al (2021)

This benefit was more pronounced in those with higher BMI

Ipamorelin's human data is limited to two published pharmacokinetic/pharmacodynamic studies: a 1999 PK/PD study (PMID: 10496658) that documented dose-response relationships and peak GH at 30-40 minutes post-injection in human volunteers, and a completed Phase II clinical trial for postoperative ileus (NCT00672074), after which ipamorelin's development for this indication was discontinued without approval