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Common symptoms of the condition include headaches, extreme tiredness and a loss of appetite

Further, while the mimetics include certain N-acyl groups as specified in Table 1 (Family 1), in the practice of various embodiments of the invention other N-acyl groups or substituted or unsubstituted phenyl groups may be used at i

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It is well known that an enzyme simultaneously presented with two alternative substrates will catalyze their reactions in the ratio between their respective catalytic efficiency multiplied with the ambient substrate concentration, k cat /K m [substrate]

This impairment results in increased apoptosis, particularly in renal proximal tubular cells, exacerbating kidney dysfunction [145]