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Tirzepatide for treating obesity: Rationale and design of the SURMOUNT clinical development program

Wegovy is FDA approved for chronic weight management, while Trulicity is approved for Type 2 diabetes management

The work done in labs today could pave the way for approved medical treatments tomorrow, but we are not there yet

Kinetic complementarity: The different half-lives (BPC-157 ~30 min vs TB-500 ~2-3 h) produce a layered tissue-repair signal: BPC-157 initiates early VEGF and angiogenic priming, while TB-500 sustains the cellular migration window for hours afterward

To monitor in vivo distribution, liposomes were loaded with the near-infrared dye DiR and administered to tumor-bearing mice