glp 1 side effects diarrhea 11 GLP-1 You Should Know About Diarrhea on a GLP? Why

Clin Gastroenterol Hepatol 2021

Abbreviations CNS: Central nervous system CVOT: Cardiovascular outcome trial GIP: Glucose-dependent insulinotropic polypeptide GIPR: Glucose-dependent insulinotropic polypeptide receptor GLP-1: Glucagon-like peptide-1 GLP-1R: Glucagon-like peptide-1 receptor GLP-1RA: Glucagon-like peptide-1 receptor agonist GPR: G-protein-coupled receptor HFpEF: Heart failure and preserved ejection fraction IEL: Intraepithelial lymphocyte LPS: Lipopolysaccharide MACE: Major adverse cardiovascular events MPGF: Major proglucagon fragment MTC: Medullary thyroid cancer NASH: Non-alcoholic steatohepatitis SGLT: Sodiumglucose cotransporter WAT: White adipose tissue References Bayliss WM, Starling EH (1902) The mechanism of pancreatic secretion

GLP-1 drugs are not antidepressants

Currently, two GLP-1 medications are FDA-approved specifically for weight loss: Wegovy (semaglutide) and Zepbound (tirzepatide)

Note that this is considered off-label prescribing.