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Type 4: dehydration fatigue What it feels like: Headaches combined with tiredness, difficulty concentrating, and dry mouth

Peer review Peer review information Nature thanks Darleen Sandoval and the other, anonymous, reviewer(s) for their contributions to the peer review of this work

9 Perspectives: strategy models, research gaps, and defining outcomes There are currently no established guidelines for how to best combine or sequence GLP-1 RAs with psychological or lifestyle interventions