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As shown in the Figure above, at the end of a month, weekly nasal administration results in significantly higher serum vitamin B12 levels than after intramuscular administration

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Chromatin pellet was removed by centrifugation (1700 g at 4 C for 10 min), supernatant (soluble nuclear lysate) was saved and treated with 1.5 l of RNase A (Qiagen, 19101) at room temperature for 15 min

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For the histological score, the epithelial tissue disorganization, crypt disorganization, immunocyte invasion, and erythrocyte invasion were quantified as show in Table 2