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Other signals can lead to de-methylation, where methylation takes the tag away, allowing the genes to be expressed

Glutathione further plays an important role in the detoxification of xeno- or endobiotics, where glutathione transferases (GTs, EC 2.5.1.18) catalyze the conjugation of glutathione to electrophilic compounds, which facilitates transport into the vacuole for metabolization (Labrou et al