Macrophage foam cell formation and cholesterol dependent inflammatory receptor signaling can be reduced by the removal of cholesterol by atheroprotective HDL and apoA-I via a number of mechanisms including ABCA1, ABCG1, SR-BI, and aqueous diffusion (Figure 2) (61,66-68) (see details below)
The cardiovascular benefits have substantial support, especially for certain clinical populations
Thyroid function changes Some studies and case reports suggest GLP-1s may lower thyroid stimulating hormone (TSH) levels, possibly through direct effects on the hypothalamic-pituitary-thyroid (HPA) axis, and delayed gastric emptying (affecting medication absorption)
Furthermore, if the addition is deemed a pretext to avoid regulationsa sham customizationcourts may view it as evidence of willful infringement or unfair competition
And there is a specific forum here: Hughes Syndrome APS Forum healthunlocked.com/hughes-s