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[DOI] [PMC free article] [PubMed] [Google Scholar] 937

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We validated these data using the antifolate-specific TS inhibitor raltitrexed 33

While native IGF-1 within physiological ranges appears safe, supraphysiological stimulation of IGF-1 receptor signaling through exogenous administration of potent analogs like IGF-1 DES could theoretically promote growth of existing pre-malignant or malignant cells, accelerate tumor progression, or support metastatic spread by enhancing cell survival and proliferation while inhibiting apoptosis