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individuals with higher BMI may experience different response patterns compared to those with lower BMI values, though all patients follow the same fixed dose titration schedules as outlined in the medication's prescribing information

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The results show a 66% reduction in the risk of T2D at three years compared to placebo treatment [52]

In particular, Lp(a) is thought to be a potential biomarker for anhedonia in male patients with unipolar and bipolar depression, although the precise mechanisms remain unclear, it is hypothesized that they may involve complex interactions among immune-inflammatory responses, lipoprotein profiles, and mood disorders [152]